配製水溶性(xìng)差的藥(yào)物(wù)

　　“這(zhè)種(zhǒng)類型的研磨機通(tōng)過(guò)將(jiāng)介(jiè)質(zhì)(珠粒)與(yǔ)材料(通常(cháng)是API)一(yī)起(qǐ)機械(xiè)移動(dòng)到液(yè)體中(zhōng)來操作(zuò)。 這(zhè)可(kě)以(yǐ)通過(guò)攪拌器(qì)或通(tōng)過攪(jiǎo)拌(bàn)容器(qì)本身來完(wán)成(chéng)。 珠子可以由各種(zhǒng)材(cái)料(liào)製(zhì)成; 但是(shì)，它們(mén)通(tōng)常(cháng)是玻璃球(qiú)，陶(táo)瓷，金屬(shǔ)或(huò)塑(sù)料(liào)。 珠(zhū)粒密度可(kě)以在2,500至7,800kg / m 3之間，尺(chǐ)寸在(zài)0.1至(zhì)10mm之(zhī)間(Kwade和(hé)Schwedes 2007)。 閉(bì)式(shì)攪拌(bàn)介質研(yán)磨(mó)機(jī)可以垂直(zhí)或水(shuǐ)平(píng)布置，並且(qiě)通(tōng)常配備有(yǒu)用(yòng)於冷卻目的的熱(rè)護套。 根據腔(qiāng)室和攪(jiǎo)拌器(qì)的(dí)幾何形狀(zhuàng)，可以(yǐ)區(qū)分三(sān)種類(lèi)型的(dí)磨(mó)機(jī)，即盤(pán)式(shì)攪(jiǎo)拌器(qì)，帶(dài)銷(xiāo)針式攪(jiǎo)拌(bàn)器的(dí)中間(jiān)磨機和(hé)環形間隙幾(jī)何(hé)形狀(zhuàng)(圖4.15)。”

　　臥式珠(zhū)(球)磨(mó)機(jī)Dispermat SL表示研磨腔(qiāng)容量(liáng)為(wéi)50 mL- 50 l實(shí)驗室用(yòng)臥(wò)式研(yán)磨(mó)機(jī)SL的(dí)示(shì)意(yì)圖(tú)

Formulating Poorly Water Soluble Drugs

　　4.3.2.2 Media (Bead) Wet-Milling

　　This type of mill operates by mechanically moving media (beads) together with the material (normally the API) in a liquid. This can be done either by means of a stirrer or by agitating the container itself. The beads can be made of various materials; however, they are normally glass spheres, ceramics, metal, or plastic. The bead densities can range between 2,500 and 7,800 kg/m 3 , with sizes between 0.1 and >10 mm (Kwade and Schwedes 2007 ) . Closed stirred media mills can be arranged either vertically or horizontally and are normally equipped with a thermal jacket for cooling purposes. According to the chamber and stirrer geometry, three types of mills can be distinguished, namely a disk stirrer, a medial mill with pin-counter-pin stirrer, and an annular gap geometry (Fig. 4.15 ).”