用於藥(yào)物輸(shū)送的(dí)納米顆粒技(jì)術(shù)

　　“市場(cháng)上(shàng)有(yǒu)許(xǔ)多珠(zhū)(球)研(yán)磨(mó)機可供使(shǐ)用(yòng)，從實驗(yàn)室(shì)規模(mó)到工(gōng)業(yè)化生(shēng)產規(guī)模(mó)的(dí)均有，產品(pǐn)能夠大規(guī)模生(shēng)產是其進入市場的一個必要條件(jiàn)，除(chú)了(liǎo)產品(pǐn)成本低，珠(zhū)(球)研磨(mó)法的一(yī)個(gè)優點(diǎn)就是能(néng)夠大(dà)規模生產(chǎn)。考(kǎo)慮(lǜ)到簡便(biàn)性(xìng)的(dí)問(wèn)題(tí)，研磨(mó)室通(tōng)常設計(jì)成六(liù)角(jiǎo)形，此時研(yán)磨室容(róng)積的(dí)76%都(dū)可以(yǐ)被研磨(mó)材料填充(chōng)。1000L的研磨機對應760L研磨(mó)材料(liào)：氧(yǎng)化(huà)鋯(gào)的表觀密(mì)度是3.96kg/L，需要(yào)2.8t的研(yán)磨(mó)材料。圖2.1給出(chū)了這(zhè)個(gè)問(wèn)題的解決方(fāng)法(fǎ)。圖中示出(chū)的(dí)是(shì)Dispermat SL珠(球)研(yán)磨機和(hé)外(wài)部(bù)的(dí)混懸容器。混(hùn)懸液(yè)通(tōng)過泵反(fǎn)復地通(tōng)過(guò)珠(球)研磨(mó)機(jī)。這種方法減少(shǎo)了(liǎo)研磨(mó)材料(liào)的重(zhòng)量，但延長了研磨(mó)時(shí)間(jiān)。”

Nanoparticle Technology for Drug Delivery

　　“There are a number of pearl mills available on the market, ranging from laboratory-scale to industrial-scale volumes. The ability for large-scale production is an essential prerequisite for the introduction of a product to the market.One advantage of the pearl mills, apart from being low-cost products, is their ability for scaling up. Assuming, for reasons of simplicity, hexagonal packaging of the milling pearls, 76% of the milling chamber volume will be filled by the pearls. In case of a 1000L mill this corresponds to 760L milling material; based on the apparent density of zircon oxide pearls being 3.69 kg/L, this corresponds to 2.8 tons of milling material.Figure 1 shows the solution for this problem, a pearl mill with an external suspension container. The suspension is continuously pumped through the pearl mill. This approach reduces the weight of the pearl mill itself, but it prolongs the milling times.”